COMT Val158Met polymorphism, cognitive stability and cognitive flexibility: an experimental examination
نویسندگان
چکیده
منابع مشابه
COMT Val158Met Polymorphism Modulates Cognitive Effects of Dietary Intervention
A common single nucleotide polymorphism (SNP) in the gene encoding catechol-O-methyltransferase (COMT), Val158Met, is thought to influence cognitive performance due to differences in prefrontal dopaminergic neurotransmission. Previous studies lend support for the hypothesis that the "at risk" genotype comprising two Val-alleles (low dopamine) might benefit more from plasticity-enhancing interve...
متن کاملRunning head: COMT AND COGNITIVE FLEXIBILITY
Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val 158 Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions. Recent evidence suggest that the Val 158 Met genotype may differentially affect cognitive stability and flexibility, in such a way that Val/Val homozygous individuals (who possess low prefrontal dopamine ...
متن کاملCOMT val158met Polymorphism and Neural Pain Processing
A functional polymorphism (val158met) of the gene coding for Catechol-O-methyltransferase (COM) has been demonstrated to be related to processing of emotional stimuli. Also, this polymorphism has been found to be associated with pain regulation in healthy subjects. Therefore, we investigated a possible influence of this polymorphism on pain processing in healthy persons as well as in subjects w...
متن کاملCatechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility.
OBJECTIVE The catechol O-methyltransferase (COMT) Val158Met polymorphism has been associated with cognitive and behavioral phenotypes in schizophrenia. Whether COMT genotype is beneficial may depend on phenotype definition. The authors examined the effects of COMT genotype on a task that distinguishes imitation from reversal learning. They hypothesized that the Val and Met alleles would be asso...
متن کاملCOMT Val158Met Polymorphism Modulates Huntington's Disease Progression
Little is known about the genetic factors modulating the progression of Huntington's disease (HD). Dopamine levels are affected in HD and modulate executive functions, the main cognitive disorder of HD. We investigated whether the Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene, which influences dopamine (DA) degradation, affects clinical progression in HD. We carried out...
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ژورنال
عنوان ژورنال: Behavioral and Brain Functions
سال: 2010
ISSN: 1744-9081
DOI: 10.1186/1744-9081-6-53